Germany Project Notice - A Novel And Green Mobile One Health Laboratory For (Re-)Emerging Infectious Disease Outbreaks


Project Notice

PNR 58611
Project Name A novel and green mobile One Health laboratory for (re-)emerging infectious disease outbreaks
Project Detail Innovative One Health solution for infectious disease detection Climate change and rising temperatures have facilitated the emergence of arboviruses that arrive in Europe through mosquitoes and ticks (arthropod vectors). Successfully monitoring zoonotic outbreaks requires a One Health approach to examine samples from humans, animals and the environment close to the vectors habitat. This makes mobile laboratories necessary for ensuring a quick response to epidemic outbreaks in remote areas. The EU-funded MOBILISE project will develop an innovative mobile One Health laboratory solution. The laboratory will receive human, animal and environmental samples and host a whole genome sequencing platform for pathogen discovery and epidemiological analysis. Pilots will be conducted in Europe (Austria, Greece and Romania) and Africa. "Mobile laboratories are becoming increasingly important for quick response to epidemic outbreaks in remote areas. Due to climate change and rising temperatures, emerging arboviruses (Crimean-Congo haemorrhagic fever virus, West Nile Virus, Rift Valley fever, Dengue fever) are finding their way into Europe through arthropod vectors (mosquitoes, ticks), and are becoming a major public health concern. Optimally monitoring zoonotic outbreaks requires a ""One Health"" approach, in which not only human, but also animal and environmental samples are analysed, as close as possible to the vectors habitat. Also returning travellers might carry haemorrhagic Ebola/Marburg virus or respiratory pathogens such as SARS-CoV-2. A survey of existing European mobile laboratory capacity revealed several shortcomings: of 193 labs, 66% were civilian, 88% were exclusively for human diagnostics, with 11% having an accredited quality management system, and only 3% had the highest bio-safety level BSL-4 needed for (haemorrhagic) arbovirus handling. MOBILISE aims to close this diagnostic gap, by developing a novel, quality-assured, mobile One Health laboratory solution, to provide BSL-4 capacity to many European countries. It will receive human/animal/environmental samples for molecular diagnostics, serology, microbiology, and host a whole genome sequencing platform for pathogen discovery and epidemiological analysis. We will further develop novel rapid diagnostic tests for BSL-3/4 pathogens, and produce results in machine-readable form. A novel AI-based ""Emergency Operating Centre and Decision Support System"" software will assist end-users in coordinating MOBILISE fleets across Europe and manage outbreaks in real-time. Hosted on an electric/hybrid truck platform, and using solar and wind-energy, it will also reduce CO2 emissions in compliance with the European Green Deal. The lab will be field-tested to TRL-7 by National agencies and first-responders in Austria, Romania, Greece and Africa."
Funded By European Union (EU)
Country Germany , Western Europe
Project Value EUR 4,379,818

Contact Information

Company Name BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN
Web Site https://cordis.europa.eu/project/id/101073982

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