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1.

UNIVERSITAT WIEN

Complicity: A Crisis of Participation in Testimonies of Totalitarianism in Contemporary German-language Literatures

  • 19 Million
  • Austria
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Complicity: A Crisis of Participation in Testimonies of Totalitarianism in Contemporary German-language Literatures
Company Name UNIVERSITAT WIEN
Country Austria , Western Europe
Project Value 19 Million
Project Detail

The aim of COMPLIT is to analyse the role of language in structures of complicity in humanitarian, political, ecological, moral and other wrongdoings that raise the question of what democratic participation means. The research project aims at interdisciplinary innovation, relating recent research in law and social sciences to testimonies of totalitarianism in contemporary German-language literatures by Herta Müller, Aglaja Veteranyi, and Elfriede Jelinek. The project expounds the comprehensive role of language in structures of participation and involvement, and highlights that the concern of testimonies of past totalitarianism is for the present: They outline modes of partaking in institutional violence that draws on heritage, culture, social, and gender distinctions still active in the globalized world of the present. The outlook onto the broader academic discussion and current societal problems strengthens the stance of humanities research by demonstrating its relevance to citizens at large. The scientific rationale of the project is a two-way knowledge transfer in the training-through-research of the applicant, who is an experienced researcher in the field of comparative literature with special regard to law and literature, and currently a research fellow at Yale University in the US. While transferring knowledge about an interdisciplinary, comparative approach to literature with a strong outlook onto societal challenges on highest international academic standards to the host institution, Universität Wien, the applicant will be reintegrated into the European research network. The COMPLIT project is of clear relevance to the Marie Sklodowska-Curie actions programme because it contributes to a better understanding of the current crisis in European integration and the backlashes onto democratic freedom by resentments and beliefs from Europe’s violent past in addressing structures of public discourses and institutions that foster antidemocratic, totalitarian notions.

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Company Name UNIVERSITAT WIEN
Address Universitatsring 1 1010 Wien
Web Site https://cordis.europa.eu/project/rcn/222661/factsheet/en

2.

UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET

Development of Deep-UV Quantitative Microscopy for the Study of Mitochondrial Dysfunction

  • 20 Million
  • Norway
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Development of Deep-UV Quantitative Microscopy for the Study of Mitochondrial Dysfunction
Company Name UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET
Country Norway , Western Europe
Project Value 20 Million
Project Detail

Mitochondria play a vital role in the cellular machinery, hence it is little surprising that their dysfunction has been linked to many diseases, from diabetes to neurodegeneration. However, as many studies on the interplay of organelles and molecular dynamics often employ fluorescence microscopy, a continued worry overshadowing findings and deductions is the possibility that the transfection-induced overexpression of fluorescent proteins skews the obtained results. A recent approach, the gene editor CRISPR-CAS9, which modifies rather than adds DNA sequences, circumvents this issue, but in turn often reduces the available signal levels. To counter low signals and yet offer highest resolution and specificity, MitoQuant aims to image contextual mitochondrial information with label-free superresolution, while simultaneously enhance image quality of specific but sparse fluorescently labelled proteins of interest through recently presented de-noising routines based on machine learning. Therefore, the development of a novel instrument to provide adequate resolution and contrast, matching label-based live-cell superresolution techniques like structured illumination microscopy, is the first main goal of this project. The proposed microscope will work in the deep UV range and employ dedicated optics originally developed for material science to provide high numerical apertures at short wavelengths, thus enabling live-cell imaging in the 100nm range. Concurrently, a neural network will be compiled and trained to enhance signals under low-light conditions and to extract and classify cellular organelles based on their quantitative phase and autofluorescence information. Building on an excellent track record of developing application-tailored microscopes as well as advanced image reconstruction and processing algorithms particularly suited for live-cell superresolution, the researcher strives to start with first live-cell experiments in good time after establishing the technique.

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Company Name UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET
Address Hansine Hansens Veg 14 9019 Tromso
Web Site https://cordis.europa.eu/project/rcn/222666/factsheet/en

3.

STICHTING KATHOLIEKE UNIVERSITEIT

Deciphering transcriptional regulation of NF-kB target genes using integrative omics approaches

  • 19 Million
  • Netherlands The
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Deciphering transcriptional regulation of NF-kB target genes using integrative omics approaches
Company Name STICHTING KATHOLIEKE UNIVERSITEIT
Country Netherlands The , Western Europe
Project Value 19 Million
Project Detail

NF-kB is a family of transcription factors that regulate expression of genes that are involved in various cellular processes such as apoptosis, proliferation and differentiation. The NF-kB pathway is implicated in the initiation and progression of cancer and cancer cell drug resistance. Unfortunately, global NF-kB inhibition is harmful to the immune system; therefore, inhibition of a subset of NF-kB target genes that are linked to malignant transformation would be more appropriate. Different NF-kB target genes display distinct transcription activation kinetics, indicating that the molecular mechanisms driving expression of NF-kB target genes are strikingly diverse. Thus, it is highly interesting to study the factors that are involved in transcriptional activation of individual NF-kB responsive genes, both from a fundamental and clinical perspective. Here, we will develop two innovative strategies based on CRISPR/Cas9 based genome targeting combined with mass spectrometry-based technology to isolate single NF-kB target gene promoters upon NF-kB pathway activation and identify their constituents. We will also apply a complementary approach, ATAC-sequencing, to identify transcription factors that are involved in activation of NF-kB responsive genes. Moreover, we will study the underlying mechanisms and characterize the function of proteins that interact with NF-kB responsive promoters. Finally, the described mechanisms discovered in cancer cell lines will be verified and validated in small intestinal organoids, a non-transformed cell model for homeostasis in the intestinal epithelium. This ambitious and multidisciplinary project will greatly benefit from my expert knowledge regarding the NF-kB pathway combined with the expertise of the host laboratory in mass spectrometry and genomics. The project is expected to have a major impact in the research area of gene expression regulation in general and molecular cancer research focusing on the NF-kB pathway in particular.

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Company Name STICHTING KATHOLIEKE UNIVERSITEIT
Address Geert Grooteplein Noord 9 6525 Ez Nijmegen
Web Site https://cordis.europa.eu/project/rcn/222663/factsheet/en

4.

UNIVERSITY OF YORK

Conserving our wildlife heritage: comparative biomechanics of feeding in native and introduced minks

  • 32 Million
  • United Kingdom
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Conserving our wildlife heritage: comparative biomechanics of feeding in native and introduced minks
Company Name UNIVERSITY OF YORK
Country United Kingdom , Western Europe
Project Value 32 Million
Project Detail

The European mink (Mustela lutreola) is the second most threatened mammal in Europe. In the last decade, its population has been halved by habitat degradation and introduction of American Mink (Neovison vison) populations. This invasive species is larger and less habitat-restricted than the European mink. It is unclear whether dietary overlap occurs between these mink species, although skull morphology would suggest that the American mink has access to a wider variety of food items. MINKS aims to compare the mechanical performance of the jaws in feeding to assess the range of potential foods and extent of dietary competition between both mink species. To accomplish this, MINKS will combine computer modelling techniques (iodine-enhanced microCT scans, finite element analysis (FEA)) with 3D geometric morphometric methods (3DGM) for statistical shape analysis. Differences in skull morphology between both mink species will be assessed, and the skull anatomy of each species will be 3D modelled and subjected to FEA, which will then be compared using 3DGM. MINKS will pair the morphological and zoological expertise of the experienced researcher (ER) with the state-of-the-art facilities for morphometrics and virtual simulation at the Centre for Anatomical and Human Sciences (CAHS), University of York (UK). This will provide the ER with the opportunity to restart his academic career and develop into an independent researcher. MINKS represents the first 3D study on muscular architecture in carnivorans, and also the first application of CAHS’ whole-system-function methodology to the study of carnivoran anatomy. The results of this research will be applied to develop innovative target-specific solutions that allow controlling American mink populations, particularly in areas where the food items available increase the survivability of the European mink. These findings will be disseminated to mink conservation projects to inform conservation strategies.

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Contact Details

Company Name UNIVERSITY OF YORK
Address Heslington Yo10 5dd York North Yorkshire
Web Site https://cordis.europa.eu/project/rcn/222662/factsheet/en

5.

OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN

The modes and outcomes of interaction of (im) mobile Kurdish women with public space: a cross-cultural comparative study of different urban contexts

  • 19 Million
  • Austria
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The modes and outcomes of interaction of (im) mobile Kurdish women with public space: a cross-cultural comparative study of different urban contexts
Company Name OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN
Country Austria , Western Europe
Project Value 19 Million
Project Detail

In the literature, not much has been reported on Kurdish urbanism in Kurdistan (a region in the Middle East traditionally inhabited mainly by Kurds) in general and women’s public space in particular, especially its socio-spatial implications for their everyday lives. For this reason, its particularities have largely remained unnoticed in the urban research debates concerning the Middle Eastern region. This is especially important if we consider Kurdish women’s interaction with public space in a cross-cultural comparative study in different urban contexts that Kurdish women have experienced. They can narrate different kinds of engagement, the challenges they are confronted with and the strategies they have gained to overcome gender inequality leading to their self-empowerment in social life. There are hardly any specific analyses concerning the modes and extent of Kurdish migrant women’s interaction with public space in European cities, particularly how this new spatial context affects their social lives and their empowerment. The number of Kurdish people is increasing in Western European cities: Based on the prestigious Institut Kurde in Paris, the most current estimates indicate the presence of about 1.5 to 1.7 million Kurds in Western Europe, out of these about 850,000 to 950,000 in Germany and 80,000 to 95,000 in Austria. Consequently, this line of research requires more attention from both international and national contexts in order to understand the experiences, challenges and needs of these urban dwellers in design and production of inclusive public spaces that are suitable for multicultural groups and that provide the possibility of an intercultural dialogue. The results of this proposed innovative research project could help find ways of making better connections between their everyday experiences as (im) migrants and public spaces as a constituent element of their social lives.

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Contact Details

Company Name OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN
Address Dr. Ignaz Seipel-Platz 2 1010 Wien
Web Site https://cordis.europa.eu/project/rcn/222664/factsheet/en

6.

UNIVERSITAT BASEL

Urban carbon dioxide Flux Monitoring using Eddy Covariance and Earth Observation

  • 19 Million
  • Switzerland
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Urban carbon dioxide Flux Monitoring using Eddy Covariance and Earth Observation
Company Name UNIVERSITAT BASEL
Country Switzerland , All Region
Project Value 19 Million
Project Detail

Monitoring CO2 emissions of urban areas has become a necessity for sustainable urban planning and climate change mitigation. The current urban inventories are based on top-down approaches that use fuel and electricity consumption statistics for determining CO2 emissions. Such approaches present consistency issues, neglect the biogenic components of the urban carbon cycle (i.e. vegetation, soil) and have restricted spatial and temporal resolution. The main goal of diFUME is to provide a robust methodology for mapping and monitoring the actual urban CO2 flux at optimum spatial and temporal scales, meaningful for urban design decisions. diFUME will develop, apply and evaluate independent models, capable to estimate all the different components of the urban carbon cycle (i.e. building emissions, traffic emissions, human metabolism, photosynthetic uptake, plant respiration, soil respiration). An innovative interdisciplinary methodology will be introduced, combining two cutting-edge technology tools, the Eddy Covariance (EC) and the latest advances in Earth Observation (EO). EC provides continuous in-situ measurements of CO2 flux at the local scale. Previous EC applications in urban areas have provided valuable insights on the holistic understanding of the urban CO2 flux according to the source/sink distribution in the highly heterogeneous urban environment. EO offers synoptic and continuous monitoring of large areas, capable of enhanced representation of the urban cover, morphology and function. Combined use of EO and EC can provide enhanced interpretation and modelling capabilities to achieve fine scale mapping and monitoring of urban CO2 flux. diFUME methodology will be developed and applied in the case study of Basel, exploiting the unique infrastructure and long-term urban EC measurements. diFUME methodology can be transferable to any city, providing an independent toolbox for consistent urban CO2 emission monitoring, supporting sustainable urban planning strategies.

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Contact Details

Company Name UNIVERSITAT BASEL
Address Petersplatz 1 4051 Basel
Web Site https://cordis.europa.eu/project/rcn/222665/factsheet/en

7.

UNIVERSITY OF BRIGHTON

unraveling nucleate boIling: MODEling, mesoscale simulatiONs and experiments

  • 21 Million
  • United Kingdom
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unraveling nucleate boIling: MODEling, mesoscale simulatiONs and experiments
Company Name UNIVERSITY OF BRIGHTON
Country United Kingdom , Western Europe
Project Value 21 Million
Project Detail

Cooling efficiency is of the upmost importance in several crucial technological applications, e.g. fuel cells and battery cooling, hybrid airplanes, drones and satellite thermal management. They have a value of several billions dollars around the world, with a critical contribution to global CO2 production. A promising approach to cope with the always higher heat fluxes requested is represented by phase changing systems which exploit the large latent heat associated with phase change to remove the heat from the hot surface. A robust and effective strategy is to deploy boiling. The basic underlying idea is simple: form vapour bubbles in a liquid in contact with the hot surface and evacuate them through a condenser. Its implementation, however, faces a number of challenges and requires solution to several fundamental problems. In any practical application the boiler efficiency depends on parameters, such as the frequency of bubble nucleation, their size, and the release rate from the hot surface. However, how to precisely control them is still not clear. BOIL-MODE-ON aims at addressing the underlying mechanism of bubble inception and departure during boiling, defining possible new routes and solutions both on the modelling and the practical implementation side. Dr. Magaletti will apply a cutting-edge methodology he developed in the context of cavitation phenomena, based on a mesoscale numerical modelling of the liquid-vapour system embedding thermal fluctuations. It will shed light on the effects of surface wettability and dissolved gas, which are two of the most complex and not yet understood topics in this field. A specific campaign of experiments will complement and support the analysis. The recognised experience of Prof. Marengo, who will supervise this project, on the experimental techniques for boiling guarantees the highest level of synergy and knowledge transfer with the applicant, further developing his research skill-set and enhancing his career prospective.

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Contact Details

Company Name UNIVERSITY OF BRIGHTON
Address Lewes Road Mithras House Bn2 4at Brighton
Web Site https://cordis.europa.eu/project/rcn/222667/factsheet/en

8.

FONDATION NATIONALE DES SCIENCES POLITIQUES

VOtIng Citizens and the Ethics of Democracy

  • 18 Million
  • France
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VOtIng Citizens and the Ethics of Democracy
Company Name FONDATION NATIONALE DES SCIENCES POLITIQUES
Country France , Western Europe
Project Value 18 Million
Project Detail

VoiCED is a project in normative democratic theory and its aim is to provide a diversified theory of political obligation for citizens, political parties and elected representatives, by taking into account how these political actors relate to each other. Since the issue of citizen competence has forcefully risen attention not only in scientific debates, but also in the public discourse, a normative analysis is called for to understand what should be expected of citizens in representative democracies. This first step is necessary in order to evaluate, first and normatively, what kind of competence citizens ought to have and, second and empirically, whether actual citizens do have the competence needed for democracy to work properly. In so doing, VoiCED will not only tie together various literatures, such as those on political obligation, democratic legitimacy, partisanship and political representation, which albeit overlapping have been rarely addressed in conjunction, but it will also intercept highly relevant debates in contemporary political science, concerning political behaviour, the rationality of voting and citizens’ competence, as well as in the public discourse, regarding the nature and value of democracy. Furthemore, VoiCED will provide the Experienced Researcher, Chiara Destri, with an unparalleled opportunity to enhance her research and teaching skills and to boost her academic career opportunities in Europe, because she will be hosted by Sciences Po, an internationally acclaimed centre in political and social science, and she will work under the supervision of Prof. Anabelle Lever, a leading expert in democratic theory. Thanks to both factors, she is confident that she will able to publish four scientific articles and to complete a book manuscript during the time of the Fellowship, as well as to set up a website in order to share the resulting theory with the public at large.

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Contact Details

Company Name FONDATION NATIONALE DES SCIENCES POLITIQUES
Address Rue Saint Guillaume 27 75337 Paris
Web Site https://cordis.europa.eu/project/rcn/222668/factsheet/en

9.

UNIVERSITY OF YORK

The Lexicalisation of Perceptual Experience

  • 34 Million
  • United Kingdom
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The Lexicalisation of Perceptual Experience
Company Name UNIVERSITY OF YORK
Country United Kingdom , Western Europe
Project Value 34 Million
Project Detail

Previous research suggests there may be underlying regularities in how languages encode perceptual experiences and in how perceptual language evolves over time. This points to the possibility that our cognitive architecture plays a role in constraining the variability in this domain of language. Substantiating this is highly relevant for the cognitive sciences, in light of recent proposals that many aspects of cognition may be more culture-specific than previously thought and that there are few, if any, universals of language. The present project takes up this goal by investigating how basic perceptual experiences (e.g. seeing, hearing, smelling) are encoded by verbs across languages and examining whether cognitive biases shape aspects of this lexical field. First, I will undertake a large-scale typological survey of perception verb lexicons to assess the extent to which they exhibit systematic patterns. Second, I will extend the search for regularities to the phylogenetic dimension, by examining whether perception verb vocabulary evolves along the same constrained pathways across three language families. Third, I will provide the first behavioural evidence to bear on the question of whether recurrent typological patterns in perception verb lexicons have their origins in cognitive biases, by conducting a novel artificial language learning experiment. This interdisciplinary project represents an ideal synergy between my research profile (linguistic typology, language change, psycholinguistics), the supervisor’s (Prof. Asifa Majid, cross-cultural psychology, word meaning) and that of the partner institution supervisor (Prof. Fiona Jordan, evolutionary and linguistic anthropology). Through its novel contribution to lexical typology, cognitive psychology, and language evolution, and by its advanced training in state-of-the-art technical skills, the project offers the ideal opportunity to relaunch my scientific career following a three-year hiatus raising two children.

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Company Name UNIVERSITY OF YORK
Address Heslington Yo10 5dd York North Yorkshire
Web Site https://cordis.europa.eu/project/rcn/222669/factsheet/en

10.

UNIVERSITY OF LEEDS

Expressivism and Normative Realism

  • 22 Million
  • United Kingdom
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Expressivism and Normative Realism
Company Name UNIVERSITY OF LEEDS
Country United Kingdom , Western Europe
Project Value 22 Million
Project Detail

Normative realism is the view that there are objective normative facts, i.e. facts about what is good, right, or rational, and many of our beliefs about these facts are true. Expressivism about normative discourse is the view that normative claims express desire-like mental states, such as attitudes of approval and disapproval, rather than ordinary beliefs. These two perspectives on normativity are in tension, yet each seems to capture something essential about normative thought: realism makes good on intuitions about truth and objectivity that seem non-negotiable from the engaged perspective of a deliberating agent, while expressivism accounts for the motivational force of normative thought and for the possibility of radical disagreement on normative matters. This project aims to reconcile normative realism and expressivism about normative discourse via three research objectives: (1) arguing that all forms of expressivism (i.e., semantic, pragmatic, meta-semantic) can be made compatible with realism; (2) defending a meta-semantic version of expressivism by isolating its philosophical benefits; (3) showing that not only is expressivism compatible with a commitment to objective normative truths, but it needs to be combined with such a commitment in order to fully account for normative disagreement. Each research objective will yield one stand-alone paper, and together they will result in a book proposal. These deliverables will help re-integrate the ER into the European philosophical community and establish him as one of the leading European experts in metaethics.

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Company Name UNIVERSITY OF LEEDS
Address Woodhouse Lane Ls2 9jt Leeds
Web Site https://cordis.europa.eu/project/rcn/222671/factsheet/en

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