Development And Validation Of Models For Alzheimers Disease-Relateddementias (Adrd) (R61/R33 - Clinical Trial Not Allowed This Foa Would Support Development And Validation Of Clinically Relevant Models Of Ad/Adrd Including Post-Tbi Dementias. Models Could Include Small Animals, Larger Animals, Ex Vivo Models, Human Ipscs, Or Other In Vitro Models. Validation Includes Internal, Face, Construct, And Predictive (To The Extent Possible) Validation. Such Validations Could Include Looking At Underlying Mechanism/Pathways, Functional Imaging, Behavior, And Other Cognitive Readouts. Independent Replication Is Also Encouraged. These Models Can Be Developed/Validated With The Goal Of Supporting Therapy Development Or Better Understanding Of Human Disease Mechanisms And Mechanisms That Uncover Predisposition To Developing Neurodegenerative Dementias. Either Way, It Is Essential That Models Reflect The Human Condition As Much As Possible. Novel Models Of Complex Pathology Or Comorbid Conditions Are Encouraged. Such Models Could Include Multiple Manipulations (Genetics, Environment, Lifestyle, Age, Etc.) To Better Reflect The Complex Interaction Of Risk Factors In Patients. New Models Need To Be Innovative And Address A Gap In The Currently Available Models
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