Mass Spectrometer – Supplying A High Resolution, Mass Selective Detector With Ms/Ms Function (Qtof) And Hplc. Hplc System 1. Isocratic Pump Programmable, Computer-Controlled, Controllable By The Data System, Time-Programmed Delivery Of An Eluent, For Buffer Systems, Flow Range From 0.01 - 10 Ml/Min, Pressure Range Up To 600 Bar Or Higher. 2. Gradient Pump Unit: Programmable, Computer-Controlled, Controllable By The Data System, Time-Programmed Delivery Of Two Eluents, Solvent Selection Valve For At Least 2 Solvents, Solvent Metering And Mixing On The High-Pressure Side, For Buffer Systems, Flow Range From 0.01 - 5 Ml/Min Or Higher, Pressure Range Up To 1000 Bar Or Higher. 3. Manual Control Of The Hplc System With Display For Current Pressure And Flow Rate. 4. Column Thermostat With A Temperature Range Of At Least 10°C To 85°C With Switching Valve For Use With 2 Columns Or More. Pressure Range Up To 1000 Bar Or Higher. Page 2 Of 4 5. Automatic Sampler For At Least 400 Samples (2 Ml), Injection Volume 1 ?L - 100 ?L, Pressure Range Up To 1000 Bar Or Higher. Can Be Tempered Up To 4 °C 6. Degasser System For All Hplc Solvents 7. A Rollable Table/Shelf System For All Hplc Components. High-Resolution Mass Spectrometer With Ms/Ms Functionality 1. Mass Resolution Of Min. 20000 (Fwhm, M/Z 100) 2. Mass Accuracy: <2 Ppm Rms Over 12 H With External Calibration. 3. Mass Range Of The Production Spectra From M/Z 10 Or Smaller To At Least M/Z 2000 4. Possibility Of Automatic Mass Calibration After Each Chromatographic Run 5. Generation Of Ms2 Spectra: Dissociation Activated By Electrons (Ead, Etd, Exd) As Well As Collision-Induced Dissociation (Cid) Must Be Possible. 6. Linear Dynamic Range Of More Than 4 Orders Of Magnitude. 7. Comparable Ms/Ms Spectra With Mass Spectrometers Installed At The Bfg (Sciex Tt 5600, Sciex Tt 6600, Sciex 6500+ Qtrap, Thermo Orbitrap Exploris 240, Thermo Orbitrap Qexactive Hf, Agilent 6550) For Setting Up And Continuing To Operate A Non-Target Database 8. The Installation Size Of The Mass Spectrometer May Do Not Exceed 160X80x200 Cm Ion Source 1. Ionization Must Be Possible Using Electrospray Ionization (Esi) With Flow Rates Of At Least 5-3000 ?L/Min. 2. Ionization With Atmospheric Pressure Ionization (Apci) With Flow Rates Of At Least 200-3000 ?L/Min Must Be Possible To Enable Soft Ionization For Maximally Sensitive Detection Of Precursor Ions. 3. The Ion Source Must Be Able To Be Cleaned Without Tools And Without Interrupting The Vacuum, As Well As Replacing Wearing Parts (E.G. Seals) And Changing The Ion Source. Vacuum System 4. The Backing Vacuum Pumps Of The Ms System Must Be Oil-Free. Rollable Laboratory Table For Lchrms System 5. Matching Rollable Laboratory Table For Lchrms System Hardware/Software For Lchrms System 6. The Control Computer On The Measuring Device (Computer 1) Is A Workstation With Windows 11, Consisting Of A Pc, Monitor, Keyboard And Mouse, Including Evaluation And Control Software And Ms Office A
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