Germany Project Notice - Large-Scale Electrosynthesis Of Borylated Azines

Project Notice

PNR 58820
Project Name Large-Scale Electrosynthesis of Borylated Azines
Project Detail The Nobel prize-winning Suzuki-Miyaura cross-coupling involves the palladium-catalysed coupling of a borylated molecule with an aryl halide and is the 2nd most used process by the pharmaceutical sector. Azines are small-molecules integral to discover and manufacture pharmaceuticals and agrochemicals. Using azines in Suzuki-Miyaura cross-coupling reactions represents the ideal solution to introduce these important motifs in discovery molecules but here is where the problems come: 1. There is currently very limited way of borylating azines. 2. Borylated azines, especially the ones containing a boron vicinal to the N-atom, are highly unstable. We urgently need chemical methods delivering borylated azines in a fast and cost-effective manner and that can then be employed in Suzuki-Miyaura cross-coupling reactions. As part of our ERC-2018-StG NEBULAR, focused on the development of novel photochemical strategies in radical chemistry, we recently identified a strategy that generates boryl radicals and provides far greater capability over any other method to both prepare and utilize borylated azines in modular fragment synthesis. B-ELECTRO aims to make the synthesis of our borylated azines workable on large scale and thus attractive to pharma and agro industries. This program provides a unique opportunity for the commercialization of our borylated materials and their utilization by end-users, thus providing innovative chemistry solutions and long-lasting impact to pharmaceutical and agrochemical industry and eventually our society.
Funded By European Union (EU)
Country Germany , Western Europe
Project Value EUR 150,000

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