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1.

HELSINGIN YLIOPISTO

Development of antagonists of vascular leakage

  • 2 Million
  • Finland
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Development of antagonists of vascular leakage
Company Name HELSINGIN YLIOPISTO
Funded By 38
Country Finland , Western Europe
Project Value 2 Million
Project Detail

Dysregulation of capillary permeability is a severe problem in critically ill patients, but the mechanisms involved are poorly understood. Further, there are no targeted therapies to stabilize leaky vessels in various common, potentially fatal diseases, such as systemic inflammation and sepsis, which affect millions of people annually. Although a multitude of signals that stimulate opening of endothelial cell-cell junctions leading to permeability have been characterized using cellular and in vivo models, approaches to reverse the harmful process of capillary leakage in disease conditions are yet to be identified. I propose to explore a novel autocrine endothelial permeability regulatory system as a potentially universal mechanism that antagonizes vascular stabilizing ques and sustains vascular leakage in inflammation. My group has identified inflammation-induced mechanisms that switch vascular stabilizing factors into molecules that destabilize vascular barriers, and identified tools to prevent the barrier disruption. Building on these discoveries, my group will use mouse genetics, structural biology and innovative, systematic antibody development coupled with gene editing and gene silencing technology, in order to elucidate mechanisms of vascular barrier breakdown and repair in systemic inflammation. The expected outcomes include insights into endothelial cell signaling and permeability regulation, and preclinical proof-of-concept antibodies to control endothelial activation and vascular leakage in systemic inflammation and sepsis models. Ultimately, the new knowledge and preclinical tools developed in this project may facilitate future development of targeted approaches against vascular leakage.

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Contact Details

Company Name HELSINGIN YLIOPISTO
Address Yliopistonkatu 3 00014 Helsingin Yliopisto
Web Site https://cordis.europa.eu/project/id/773076

2.

Univerzitet u Novom Sadu, Poljoprivredni fakultet Novi Sad

Evolvable platform for programmable nanoparticle-based cancer therapies

  • 3 Million
  • Serbia
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Evolvable platform for programmable nanoparticle-based cancer therapies
Company Name Univerzitet u Novom Sadu, Poljoprivredni fakultet Novi Sad
Funded By 38
Country Serbia , Southern Europe
Project Value 3 Million
Project Detail

EVO-NANO aims to create an integrated cross-disciplinary platform for the artificial evolution and assessment of nanoparticle-based drug delivery systems. Nanoparticles (NP) are increasingly being studied in cancer research for their ability to improve diagnosis accuracy and/or deliver tailored treatments directly to tumours. However, their effective biodistribution is still a major limitation. The challenge is to discover how to program collective behaviour of the trillions of NP interacting in a complex tumour environment. Finding effective NP designs that give rise to desired outcome will require a new class of evolutionary algorithms that can simultaneously 1) generate novel NP-based anti-cancer strategies, 2) search over a large space of solutions, and 3) adapt to a wide variety of scenarios. Our novel evolutionary approach will be integrated with PhysiCell (http://physicell.mathcancer.org) and NanoDoc (http://nanodoc.org) simulators that reproduces realistic NP motion and interactions within the tumour environment and with other NP. The most promising NP designs will then be synthesized and tested in vivo and in vitro on breast and colon cancer stem cells using mouse cancer xenografts and microfluidic testbeds featuring cancer microenvironments. To promote translation of the platform from early stage research into a commercialized product for patients, we will work with industrial partner ProChimia Surfaces, organize ‘Industry Open Days’ for potential investors and develop a translation strategy. EVO-NANO is a multidisciplinary project that will create an entirely novel NP design platform for new cancer treatments, capable of autonomously evolving both innovative and adaptive solutions. The proposed platform has the potential to be at the forefront of cancer nanomedicine by enabling much faster development and assessment of new cancer treatments, than is done today. The project will generate concrete tools for the predictive design of nanomedicines that could be applied in other clinical fields.

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Company Name Univerzitet u Novom Sadu, Poljoprivredni fakultet Novi Sad
Address Trg Dositeja Obradovica 8 21000 Novi Sad
Web Site https://cordis.europa.eu/project/id/800983

3.

WEIZMANN INSTITUTE OF SCIENCE

Novel strategies for mammalian cardiac repair

  • 2 Million
  • Israel
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Novel strategies for mammalian cardiac repair
Company Name WEIZMANN INSTITUTE OF SCIENCE
Funded By 38
Country Israel , Western Asia
Project Value 2 Million
Project Detail

Recent ground-breaking studies by my team and others demonstrated that latent heart regeneration machinery can be awakened even in adult mammals. My lab’s main contribution is the identification of two, apparently different, molecular mechanisms for augmenting cardiac regeneration in adult mice. The first requires transient activation of ErbB2 signalling in cardiomyocytes and the second involves extra cellular matrix-driven signalling by the proteoglycan agrin. Impressively, both mechanisms promote a major regenerative response that, in turn, enhances cardiac repair. In CardHeal we will use the two powerful regenerative models to obtain a holistic view of cardiac regeneration and repair mechanisms in mammals (mice and pigs). In Aim 1, we will explore the molecular mechanisms underlying our discovery that transient activation of ErbB2 in adult cardiomyocytes results in massive cardiomyocyte dedifferentiation and proliferation followed by new vessels formation, scar resolution and functional cardiac repair. Specific objectives focus on ErbB2-Yap/Hippo signalling during cardiac regeneration; ErbB2 activation in a chronic heart failure model; ErbB2-induced regenerative EMT-like process; and cardiomyocyte re-differentiation. In Aim 2, we will investigate the therapeutic effects of agrin, whose administration into injured hearts of mice and pigs elicits a significant regenerative response. Specific objectives are matrix-related cardiac regenerative cues, modulation of the immune response, angiogenesis, matrix remodeling, and developing a preclinical, large animal model to study agrin efficacy for cardiac repair. Interrogating the differences and similarities between our two regenerative models should give us a detailed roadmap for cardiac regenerative medicine by providing deeper knowledge of the regenerative process in the heart and pointing to novel targets for cardiac repair in human patients.

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Contact Details

Company Name WEIZMANN INSTITUTE OF SCIENCE
Address Herzl Street 234 7610001 Rehovot
Web Site https://cordis.europa.eu/project/id/788194

4.

THE HEBREW UNIVERSITY OF JERUSALEM

The Claustrum: A Circuit Hub for Attention

  • 2 Million
  • Israel
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The Claustrum: A Circuit Hub for Attention
Company Name THE HEBREW UNIVERSITY OF JERUSALEM
Funded By 38
Country Israel , Western Asia
Project Value 2 Million
Project Detail

Our senses face a constant barrage of information. Hence, understanding how our brain enables us to attend to relevant stimuli, while ignoring distractions, is of increasing biomedical importance. Recently, I discovered that the claustrum, a multi-sensory hub and recipient of extensive neuromodulatory input, enables resilience to distraction. In my ERC project, I will explore the mechanisms underlying claustral mediation of resilience to distraction and develop novel approaches for assessing and modulating attention in mice, with implications for humans. Transgenic mouse models that I identified as enabling selective access to claustral neurons overcome its limiting anatomy, making the claustrum accessible to functional investigation. Using this novel genetic access, I obtained preliminary results strongly suggesting that the claustrum functions to filter distractions by adjusting cortical sensory gain. My specific aims are: 1) To delineate the mechanisms whereby the claustrum achieves sensory gain control, by applying in-vivo cell-attached, multi-unit and fiber photometry recordings from claustral and cortical neurons during attention-demanding tasks. 2) To discriminate between the functions of the claustrum in multi-sensory integration and implementation of attention strategies, by employing multi-sensory behavioral paradigms while modulating claustral function. 3) To develop validated complementary physiological and behavioral protocols for adjusting claustral mediation of attention via neuromodulation. This study is unique in its focus and aims: it will provide a stringent neurophysiological framework for defining a key mechanism underlying cognitive concepts of attention, and establish a novel platform for studying the function of the claustrum and manipulating its activity. The project is designed to achieve breakthroughs of fundamental nature and potentially lead to diagnostic and therapeutic advances relevant to attention disorders.

Sector Administration & Marketing

Contact Details

Company Name THE HEBREW UNIVERSITY OF JERUSALEM
Address Edmond J Safra Campus Givat Ram 91904 Jerusalem
Web Site https://cordis.europa.eu/project/id/770951

5.

UNIVERSITY OF DUNDEE

mRNA cap regulation and function in CD8 T cells

  • 2 Million
  • United Kingdom
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mRNA cap regulation and function in CD8 T cells
Company Name UNIVERSITY OF DUNDEE
Funded By 38
Country United Kingdom , Western Europe
Project Value 2 Million
Project Detail

CD8 T cells are vital for our response to infection, directly killing infected cells and stimulating other cells of the immune system. Major health problems world-wide involve deregulated T cells, including lymphomas, leukaemias, auto-immune disorders and organ transplant rejection. Damaging deficiencies of T cells are found in old-age. T cell development and response to pathogens is driven by regulated transcription and translation, however the mechanisms orchestrating this gene regulation are largely unknown, and are likely provide novel opportunities for therapeutic intervention. Our preliminary data reveals that a potent structure in gene expression, the mRNA cap, which co-ordinates RNA processing and translation initiation, is crucial for the development and activation of CD8 T cells. Regulation of mRNA cap formation is a novel concept in gene regulation in T cells, and also has not been studied in vivo previously. Our findings suggest the existence of an mRNA cap code, in which the different mRNA cap methylations regulate different genes and cellular functions. In TCAPS we will reveal how the mRNA cap code orchestrates CD8 T function. We will determine how the mRNA cap structures are regulated during CD8 T cell differentiation using the latest mass spectrometry technologies. We will determine the role of each mRNA cap methyltransferase in CD8 T cell gene expression during differentiation, using conditional knock-out mice in conjunction with enzyme biochemistry, RNA sequencing and quantitative mass spectrometry. We will determine the biological function of the mRNA cap methyltransferases in CD8 T cell survival and activation using immunological assays. TCAPS will also provide the first insight into the role of the mRNA cap code in vivo. The mRNA cap code is likely to be operational throughout mammalian physiology and therefore TCAPS will contribute significantly to our understanding of regulated gene expression in mammals.

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Company Name UNIVERSITY OF DUNDEE
Address Nethergate Dd1 4hn Dundee
Web Site https://cordis.europa.eu/project/id/769080

6.

INSTITUTE OF SCIENCE AND TECHNOLOGYAUSTRIA

The Brainstem-Hippocampus Network Uncovered: Dynamics, Reactivation and Memory Consolidation

  • 1,74,167
  • Austria
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The Brainstem-Hippocampus Network Uncovered: Dynamics, Reactivation and Memory Consolidation
Company Name INSTITUTE OF SCIENCE AND TECHNOLOGYAUSTRIA
Funded By 38
Country Austria , Western Europe
Project Value 1,74,167
Project Detail

Memory formation may rely on the brainstem and hippocampus being in sync Structural and functional maps of the brain and brainstem have shed important light on neuronal circuits and their interconnections. When combined with behavioural studies, interconnected activity can be linked to higher functions. While the hippocampus has long been known to play a key role in memory processes, the role of the brainstem in memory remains largely unknown. However, synchronised activity has been linked to memory formation, and the brainstem modulates it during sleep and wakefulness. DREAM is simultaneously recording neuronal activity in the brainstem and hippocampus in mice performing a memory task or asleep mice. Advanced signal processing and machine learning could provide a model of the dynamic interactions between the brainstem and hippocampus and their relation to memory processes.

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Company Name INSTITUTE OF SCIENCE AND TECHNOLOGYAUSTRIA
Address Am Campus 1 3400 Klosterneuburg
Web Site https://cordis.europa.eu/project/id/841301

7.

JUSTINMIND SL

Justinmind XR: The First Code-Free Rapid Prototyping Platform for eXtended Reality (VR/AR/MR) and Spatial Computing

  • 2 Million
  • Spain
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Justinmind XR: The First Code-Free Rapid Prototyping Platform for eXtended Reality (VR/AR/MR) and Spatial Computing
Company Name JUSTINMIND SL
Funded By 38
Country Spain , Western Europe
Project Value 2 Million
Project Detail

Software development apps with no coding The foundation of the personal computer revolution is the graphical user interface and a mouse. Moving away from the flat screen to a 3D world, the EU-funded JUSTINMIND-XR project will facilitate the journey to immersive technologies that can merge the physical and virtual worlds. It is developing the first rapid prototyping platform (RPP) for designing spatial computing software applications in a more natural and intuitive design for immersive 3D environments. Powered by big data analytics, deep learning and full drag&drop, it’s the first 100 % code free platform. In fact, it will be the first SaaS cloud platform to design eXtended Reality applications without writing any code. With no-code, users do not need coding knowledge to create apps.

Sector Administration & Marketing

Contact Details

Company Name JUSTINMIND SL
Address Avenida Meridiana 354 P13 08027 Barcelona
Web Site https://cordis.europa.eu/project/id/873537

8.

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

Early embryonic events, life-long consequences: DNA methylation dynamics in mammalian development

  • 1 Million
  • France
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Early embryonic events, life-long consequences: DNA methylation dynamics in mammalian development
Company Name CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Funded By 38
Country France , Western Europe
Project Value 1 Million
Project Detail

Gene activation gone awry in embryos can have lifelong effects Epigenetic changes are heritable changes in gene expression. They do not change the underlying DNA sequence coding in the gene but rather how a cell reads the gene. Given that these changes are inherited in daughter cells, epigenetic changes occurring immediately after fertilisation can have lifelong effects on an organism. DNA methylation, the addition of a methyl group (CH3), is an epigenetic change that usually leads to gene repression. One such instance during mouse embryogenesis leads to activation of the associated gene. When it does not occur, the gene is silent forever and the mice do not grow properly. DyNAmecs is investigating this unconventional effect of DNA methylation, epigenetic changes during this critical point of development, and their long-lasting effects.

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Company Name CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Address Rue Michel Ange 3 75794 Paris
Web Site https://cordis.europa.eu/project/id/851054

9.

WEIZMANN INSTITUTE OF SCIENCE

New Target and Drug Candidates for Alleviating Chronic Pain

  • Plz Refer Document
  • Israel
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New Target and Drug Candidates for Alleviating Chronic Pain
Company Name WEIZMANN INSTITUTE OF SCIENCE
Funded By 38
Country Israel , Western Asia
Project Value Plz Refer Document
Project Detail

Insensitive mice may elucidate a path to relief for chronic pain Estimates suggest that at least one in five people globally suffer from chronic pain. Aside from impairing a persons ability to perform activities of daily living, chronic pain can lead to a chronic stress reaction. This can increase blood pressure and heart rate and result in other harmful effects on health including reduced immunity to illnesses and diseases. Knockdown of a specific gene in mice leads to reduced sensitivity to pain, and researchers have now identified several existing drugs that could mimic this effect. EU funding of the ChronicPain project is helping these researchers exploit their discovery, using it to test approved and candidate drugs on the path to relief for millions of people suffering with chronic pain.

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Company Name WEIZMANN INSTITUTE OF SCIENCE
Address Herzl Street 234 7610001 Rehovot
Web Site https://cordis.europa.eu/project/id/875328

10.

UNIVERSITE CATHOLIQUE DE LOUVAIN

Exploiting the pathophysiology of the gut towards innovative oral peptide delivery strategies

  • 1 Million
  • Belgium
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Exploiting the pathophysiology of the gut towards innovative oral peptide delivery strategies
Company Name UNIVERSITE CATHOLIQUE DE LOUVAIN
Funded By 38
Country Belgium , Western Europe
Project Value 1 Million
Project Detail

Bioactive nanocarriers as an oral peptide delivery strategy Development of a novel oral drug delivery system for therapeutic peptides is a major challenge in the treatment of chronic diseases such as type 2 diabetes. This EU-funded project will work on the application of nanocarriers for peptide delivery, which protects its cargo against chemical and enzymatic degradation while enabling controlled release, targeting and increased bio-availability. Project strategy stems from an earlier observation that lipid-based nanocarriers themselves trigger endogenous bio-active peptide secretion in vivo after oral administration to mice. Current research will aim to develop a dual-action delivery system that combines the biological effect of the nanocarriers and that of the encapsulated drug to enable complex and very efficient treatments for gastrointestinal disorders.

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Company Name UNIVERSITE CATHOLIQUE DE LOUVAIN
Address Place De L Universite 1 1348 Louvain La Neuve
Web Site https://cordis.europa.eu/project/id/850997

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