Tenders Are Invited For Research Service Contract For Gmp-Compliant Process Development, Upscaling And Test ... in Germany

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Age-Related Macular Degeneration (Amd) Is The Most Common Cause Of Blindness In Germany. One In Four People Over The Age Of 60 Will Be Affected By The Disease. In Germany Alone, Around 7 Million People Suffer From This Disease (~200 Million People Worldwide). In Amd, The Cone Photoreceptor Cells (Cone Prs), Which Are Important For Central Vision, Reading, Color Vision, And Face Recognition, Degenerate. Their Loss Leads To Severe Limitations And Significantly Reduces The Quality Of Life. There Are Two Forms Of Amd, And There Is Currently No Cure For Either. We Have Developed A Patented Process To Produce Cone Prs From Human Induced Stem Cells In Large Quantities And In A Short Time (<3 Weeks). By Overexpressing Three Transcription Factors In Human Induced Pluripotent Stem Cells (Hipscs), We Can Generate 50% Cone Pr Progenitor Cells Within 10 Days. These Adherent Cells Are Currently Produced Using Standard Laboratory Procedures. As Part Of A Research Project, Our Technology Will Be Developed Towards Cell Replacement Therapy For Both Forms Of Amd. The Aim Of The Research Project Is A Proof-Of-Principle (Pop) Of This Procedure In An In Vivo Study In A Large Animal Model. As Part Of The Research Project, A Gmp-Compliant Manufacturing Process For Our Cell Material Based On Hipscs Is To Be Developed, Which Can Be Transferred To An Industrial Scale. After Establishing The Process, Developing Suitable Quality Controls And Upscaling The Process, The Cell Batch Should Be Produced For In Vivo Transplantation.

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