| Project Detail |
Mechanistic insight into T cell infiltration into tumours
T cells have the potential to recognise and attack tumour cells, generating anti-cancer immunity. However, tumours and their immediate microenvironment have evolved biochemical and physical mechanisms that restrict access to T cells and also resist most available therapies. Funded by the European Research Council, the DRILL project aims to delineate the mechanisms of T cell migration to tumours by focusing on chemokine production in the tumour microenvironment and the inherent ability of T cells to infiltrate tumours. Results will help understand how T cell tumour infiltration is regulated, thereby advancing T cell-based immunotherapies for solid tumours such as pancreatic ductal adenocarcinoma. |
