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1.

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Development of Stereoselective Olefin Functionalization Methods

  • 2 Million
  • Switzerland
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Development of Stereoselective Olefin Functionalization Methods
Company Name EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Funded By 38
Country Switzerland , Western Europe
Project Value 2 Million
Project Detail

The ability toThe ability to readily access small-molecule building blocks at will has important consequences for the discovery and development of novel medicines and materials. It is particularly beneficial when the chemical methods are convenient while at the same time economically and environmentally tenable and sustainable. We are especially interested in catalytic processes that are easily executed and utilize readily available starting materials to produce optically active products with high regio, chemo, diastereo, and enantioselectivity. The proposal aims to discover, develop, and study a collection of enantioselective olefin functionalization reactions that provide access to useful building blocks, such as amines, azides, hydrazines, nitriles, alcohols, involving acyclic, cyclic and bicyclic structures. The catalyst will be derived from earth abundant metals, such as Fe, Mn, and Co and incorporate novel chiral ligands. The study includes the design and preparation of two structural classes of novel, chiral boric acids that are expected to serve as catalyst for the enantioselective functionalization of unsaturated carboxylic acids and boronic acids. The methods are expected to substantially impact the development of novel strategies for complex molecule synthesis. In this regard, we propose to use the catalysts form this study to convert dienes and trienes into polyols with characteristic stereochemical and oxidation patterns found in bioactive agents, including pharma- and nutraceuticals (carnitine). Such advances enable new approaches that go beyond the well-established methods such as aldol/allylation for the preparation of stereochemically complex fragments. Catalysts will also be developed that convert acyclic olefinic alcohols and amines into optically active, saturated furans, pyrans, pyrrolidines, and piperidines. The implementation of the various catalytic methods in complex settings enables efficient, convergent routes to bioactive agents.

Sector Administration & Marketing

Contact Details

Company Name EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Address Raemistrasse 101 8092 Zuerich
Web Site https://cordis.europa.eu/project/rcn/222616/factsheet/en

2.

University of Bath

A Radical Approach to C-H Alkylation

  • 261,307
  • United Kingdom
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A Radical Approach to C-H Alkylation
Company Name University of Bath
Funded By 107
Country United Kingdom , Western Europe
Project Value 261,307
Project Detail

Organic chemistry has transformed the way we live. It has allowed us to create molecules to treat disease, to grow crops to sustain our population, and to create high-tech materials used in modern technology. Organic molecules by their very nature contain dozens of C-H bonds which make up their hydrocarbon framework, but these are typically "inert" and unreactive. The field of C-H functionalisation aims to find ways of selectively replacing one or more of these C-H bonds with other chemical groups, allowing chemists to build up molecules in a much more efficient, cost-effective and sustainable fashion. Given the dramatic alterations of chemical and biological properties that can arise from the incorporation of simple aliphatic groups (e.g., Me, Et, i-Pr), the alkylation of C-H bonds is considered to be one of the most desirable substitutions from a structural-diversification viewpoint. However, despite some spectacular advances in this area, C-H alkylation is still not a routine disconnection in organic synthesis. In the case of C(sp3)-H bonds in aliphatic compounds, most solutions to the problem have relied upon hydrogen atom abstraction to generate alkyl radical intermediates, followed by trapping of these radicals with alkylating agents. As radicals alone do not possess the necessary reactivity to engage saturated alkyl electrophiles directly, transition metals such as nickel have been used to usher the radical intermediates into organometallic catalytic cycles. However, a reliance on transition metal catalysts to forge C(sp3)-C(sp3) linkages can lead to problems in a drug development setting, as these catalysts are prone to poisoning by the basic functionalities commonly encountered in drug-like molecules (e.g., amines, certain heteroaromatics). Additionally, trace metal contamination is a serious concern in a pharmaceutical setting. For these reasons, a metal-free approach to C(sp3)-H bond alkylation could prove transformative in organic synthesis. In this project, we will develop a conceptually-distinct approach to the catalytic alkylation of C(sp3)-H bonds - to install simple alkyl groups - that does not require organometallic catalysis. Given the recent industry call for methods that "tolerate nitrogen heteroatoms and (unprotected) polar functional groups", our efforts will be focused primarily on the C(sp3)-H alkylation of aliphatic amines. Mild, catalytic protocols for the substitution of alpha-C-H bonds in unprotected amines with simple alkyl groups are currently unknown, and the invention of robust procedures to effect these transformations would constitute a step-change in the synthesis of small molecule drugs. After all, two of the top ten most widely-used synthetic methods in medicinal chemistry (i.e., N-alkylation and reductive amination) are specifically used to target substituted amines, but both rely on C-N as opposed to C-C bond formation. Tellingly, the third most utilised reaction in the pharmaceutical industry is addition or removal of amine N-protecting groups (i.e., Boc), which inherently speaks to a paucity of synthetic methods compatible with unprotected amines. Given that over 80% of drugs or drug candidates contain amine functionality, it is clear that new and enabling synthetic methods to access complex amines in a scalable and sustainable fashion would have demonstrable impact upon the health and wellbeing of our society.

Sector Administration & Marketing

Contact Details

3.

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Advancing CO2 Capture Materials by Atomic Scale Design: the Quest for Understanding

  • 2 Million
  • Switzerland
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Advancing CO2 Capture Materials by Atomic Scale Design: the Quest for Understanding
Company Name EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Funded By 38
Country Switzerland , Western Europe
Project Value 2 Million
Project Detail

Carbon dioxide capture and storage is a technology to mitigate climate change by removing CO2 from flue gas streams or the atmosphere and storing it in geological formations. While CO2 removal from natural gas by amine scrubbing is implemented on the large scale, the cost of such process is currently prohibitively expensive. Inexpensive alkali earth metal oxides (MgO and CaO) feature high theoretical CO2 uptakes, but suffer from poor cyclic stability and slow kinetics. Yet, the key objective of recent research on alkali earth metal oxide based CO2 sorbents has been the processing of inexpensive, naturally occurring CO2 sorbents, notably limestone and dolomite, to stabilize their modest CO2 uptake and to establish re-activation methods through engineering approaches. While this research demonstrated a landmark Megawatt (MW) scale viability of the process, our fundamental understanding of the underlying CO2 capture, regeneration and deactivation pathways did not improve. The latter knowledge is, however, vital for the rational design of improved, yet practical CaO and MgO sorbents. Hence this proposal is concerned with obtaining an understanding of the underlying mechanisms that control the ability of an alkali metal oxide to capture a large quantity of CO2 with a high rate, to regenerate and to operate with high cyclic stability. Achieving these aims relies on the ability to fabricate model structures and to characterize in great detail their surface chemistry, morphology, chemical composition and changes therein under reactive conditions. This makes the development of operando and in situ characterization tools an essential prerequisite. Advances in these areas shall allow achieving the overall goal of this project, viz. to formulate a roadmap to fabricate improved CO2 sorbents through their precisely engineered structure, composition and morphology.

Sector Administration & Marketing

Contact Details

Company Name EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Address Raemistrasse 101 8092 Zuerich
Web Site https://cordis.europa.eu/project/rcn/220133/factsheet/en

4.

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Advancing CO2 Capture Materials by Atomic Scale Design: the Quest for Understanding

  • 2 Million
  • Switzerland
view notice less notice
Advancing CO2 Capture Materials by Atomic Scale Design: the Quest for Understanding
Company Name EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Funded By 38
Country Switzerland , Western Europe
Project Value 2 Million
Project Detail

Carbon dioxide capture and storage is a technology to mitigate climate change by removing CO2 from flue gas streams or the atmosphere and storing it in geological formations. While CO2 removal from natural gas by amine scrubbing is implemented on the large scale, the cost of such process is currently prohibitively expensive. Inexpensive alkali earth metal oxides (MgO and CaO) feature high theoretical CO2 uptakes, but suffer from poor cyclic stability and slow kinetics. Yet, the key objective of recent research on alkali earth metal oxide based CO2 sorbents has been the processing of inexpensive, naturally occurring CO2 sorbents, notably limestone and dolomite, to stabilize their modest CO2 uptake and to establish re-activation methods through engineering approaches. While this research demonstrated a landmark Megawatt (MW) scale viability of the process, our fundamental understanding of the underlying CO2 capture, regeneration and deactivation pathways did not improve. The latter knowledge is, however, vital for the rational design of improved, yet practical CaO and MgO sorbents. Hence this proposal is concerned with obtaining an understanding of the underlying mechanisms that control the ability of an alkali metal oxide to capture a large quantity of CO2 with a high rate, to regenerate and to operate with high cyclic stability. Achieving these aims relies on the ability to fabricate model structures and to characterize in great detail their surface chemistry, morphology, chemical composition and changes therein under reactive conditions. This makes the development of operando and in situ characterization tools an essential prerequisite. Advances in these areas shall allow achieving the overall goal of this project, viz. to formulate a roadmap to fabricate improved CO2 sorbents through their precisely engineered structure, composition and morphology.

Sector Administration & Marketing

Contact Details

Company Name EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Address Raemistrasse 101 8092 Zuerich
Web Site https://cordis.europa.eu/project/rcn/220133/factsheet/en

5.

PT Pertamina

Balikpapan Refinery Expansion Phase I and II

  • 57,800 Trillion
  • Indonesia
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Balikpapan Refinery Expansion Phase I and II
Company Name PT Pertamina
Funded By 0
Country Indonesia , South-Eastern Asia
Project Value 57,800 Trillion
Project Detail

PROJECT TYPE Refinery expansion LOCATION East Kalimantan, Indonesia EXPECTED COMPLETION Phase one: 2019, Phase two: 2021 ESTIMATED INVESTMENT IDR57.8bn ($4bn) DEVELOPER PT Pertamina CONTRACTORS SK Engineering & Construction, Hyundai Engineering, PT Rekayasa Industri, PT PP (Persero), WorleyParsons Balikpapan refinery, located on Borneo Island in East Kalimantan, Indonesia, is being expanded by its owner PT Pertamina (Persero) in order to increase its capacity by adding new processing units. The expansion project is part of the IDR246.2trn ($17bn) Refinery Development Master Plan (RDMP) programme launched by the Indonesian government to revamp and upgrade five refineries in the country. The facilities to be updated are the Cilacap refinery in Central Java, the Balongan refinery in West Java, the Dumai refinery in Riau, the Balikpapan refinery in East Kalimantan and the Plaju refinery in South Sumatra. The RDMP will improve the country’s energy security, as well as increase the production capacity of the refineries by 150%. The Balikpapan expansion will see production rise from 260,000 barrels per day (bpd) to 360,000bpd and enable the refinery to produce high-quality fuels of Euro V standard. The project will be undertaken in two phases with a total estimated investment of IDR57.8bn ($4bn). The first phase is expected to be completed by the end of 2019, while the second phase is targeted for completion in 2021. Balikpapan refinery expansion details The Balikpapan refinery expansion project will add a residual fluid catalytic cracker (RFCC) unit with design capacity of 90,000 barrels per stream per day (bpsd), a liquefied petroleum gas (LPG) sulphur removal unit, a propylene recovery unit and a 80,000bpsd middle distillate hydrotreater. There will also be units for naphtha hydrotreating, continuous catalytic reforming, alkylation, kerosene hydrotreating, diesel hydrotreating and hydrogen production, as well as a steam methane reformer (SMR) with a capacity of 120,000Nm³/h. Other units planned to be added to the refinery will be an isomerisation unit, saturated gas concentration unit (GCU), amine treater and regenerator, as well as caustic and LPG treaters. The new units will be built on 75ha of land. The gasoline produced by the RFCC unit will be processed in a selective hydrogenation unit (SHU) with a capacity of 48,000bpsd, using Axen’s Prime-G+TM technology to produce ultra-clean gasoline. The existing vacuum distillation unit (VDU), crude distillation unit (CDU), hydrocracker unit (HCU) and LPG recovery units will also be upgraded as part of the project. The production of Euro V gasoline, diesel and LPG will increase respectively by 100,000bpd, 30,000bpd and 930t per day. Infrastructure facilities Pertamina will upgrade the Lawe-Lawe terminal to add the facilities and infrastructure required for the units. A single point mooring system and a pipeline end manifold capable of handling crude carriers with 320,000DWT will be developed. In addition, a sulphur jetty, a jetty extension area, mooring dolphins and shipping navigation assistance facilities will be developed. A 20in diameter onshore pipeline from the Lawe-Lawe terminal to the Panajam terminal and a 52in diameter offshore pipeline from Panajam terminal to Balikpapan refinery will also be constructed. Other infrastructure facilities planned to be added to the refinery are a water treatment plant, steam and power generation plant, as well as an instrument air and nitrogen unit and tankage system, consisting of two new crude storage units with a capacity of 100 million barrels. Site development work covering an area of 97,936m², construction of 11,351m² of workshops and a warehouse covering 24,240m² are also part of the project. Contractors involved Four companies including SK Engineering & Construction, Hyundai Engineering, PT Rekayasa Industri and PT PP (Persero) are jointly undertaking the project. WorleyParsons was contracted to provide project management consultancy services for the engineering, procurement and construction (EPC) packages. Pertamina licensed Axens Technologies and Air Liquide Engineering & Construction’s process technologies for the new units. WIKA was awarded the contract for site development and construction of the jetty, while Bechtel International carried out the front-end engineering design studies for the Balikpapan refinery expansion.

Sector Administration & Marketing

Contact Details

Company Name PT Pertamina
Address Jl. Medan Merdeka Timur 1A Jakarta 10110 Indonesia Phone: 1-500-000
Email pcc@pertamina.com
Web Site https://www.hydrocarbons-technology.com/projects/balikpapan-refinery-expansion/

6.

CORROLYTIC GMBH

Commercialisation of a unifying green VCI anti-corrosion paper for the manufacturing industry and logistics companies

  • 71,429
  • Germany
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Commercialisation of a unifying green VCI anti-corrosion paper for the manufacturing industry and logistics companies
Company Name CORROLYTIC GMBH
Funded By 38
Country Germany , Western Europe
Project Value 71,429
Project Detail

Corrosion of transported goods causes economic damage of more than 3% of the world’s gross domestic product according to the World Corrosion Organization. During transport and storage cargo is prone to temperature fluctuations, humidity and oxygen yielding the risk of corrosion. Volatile corrosion inhibitors (VCI) protect goods from corrosion. Nowadays VCI substances are based on hazardous amines, nitrites, benzotriazol or tolyltriazol forming nitrosamines which are carcinogenic. Concurrently legal environmental protection standards and the consumer and producer awareness for a sustainable environment increase. Another disadvantage of today’s VCI-active substances is, that they have to be applied on the corrosion protection paper after the paper production instead of being incorporated during the production process. In addition for each metal class, i.e. cast iron, ferrous and non-ferrous metals, a special VCI blend is necessary. Applying the wrong paper for the product to be protected represents a deleterious corrosion surface and causes damage. Manufacturers and logistics companies aim for a reliable, sustainable and all-for-one anti-corrosion packaging paper at cost-efficient prices. Corrolytic’s innovation, the novel VCI paper COPROcell, is the first green corrosion protection paper doing without toxic substances unifying corrosion protection of all metal classes in one product. In Phase 1 Corrolytic explores the technical and commercial feasibility and compatibility of COPROcell. In the project the basis is set to bring COPROcell to the market. Focus will lie on the IP assessment and management. We intend to conduct market studies and technological improvements. Corrolytic is a pioneer in green VCI technology with outstanding technological and commercial experience and an extensive stakeholder network. The ambitious start-up developed six products in the past two years and holds several utility models.

Sector Administration & Marketing

Contact Details

Company Name CORROLYTIC GMBH
Address CORROLYTIC GMBH Address Ludwig-Seiboldt-Str. 9 35423 Lich Germany
Web Site https://cordis.europa.eu/project/rcn/218873/factsheet/en

7.

Saudi Aramco

Jizan Export Renery - Sour Water Stripper & Amine Regeneration

  • 500 Million
  • Saudi Arabia
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Jizan Export Renery - Sour Water Stripper & Amine Regeneration
Company Name Saudi Aramco
Funded By -
Country Saudi Arabia , Western Asia
Project Value 500 Million
Project Detail

Saudi Aramco - Jizan Export Renery - Sour Water Stripper & Amine Regeneration Unit Jizan Oil, Rening 500 Construction 2015-Q2 2018-Q4

Sector Oil, Refining

Contact Details

Company Name Saudi Aramco
Address P.O. Box 5000 Dhahran 31311, Saudi Arabia Telex: 801220 A SAO SJ Cable: ARAMCO DAMMAM Email: webmaster2@aramco.com
Web Site http://saudi-commerce.com.sa/docs/default-source/default-document-library/Projects-update/saudi-projects-update-july-2018.pdf?sfvrsn=2

8.

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

Overcoming the Selectivity Challenge in Chemistry and Chemical Biology via Innovative Tethering Strategies

  • 2 Million
  • Switzerland
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Overcoming the Selectivity Challenge in Chemistry and Chemical Biology via Innovative Tethering Strategies
Company Name ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Funded By European Union
Country Switzerland , Western Europe
Project Value 2 Million
Project Detail

In the last two centuries, synthetic organic chemistry has undergone an unprecedented revolution. The ability to understand and modify the molecular structure of matter has changed our life in many areas, such as medicine, agriculture or commodity materials. These major successes gave the impression that synthetic chemistry is a mature field. However, this impression is completely misleading, as current synthetic methods still lack the selectivity needed for the modification of complex molecules. Both selecting between different reactive groups and functionalizing inert bonds in their presence represent formidable challenges. In this project, we propose to develop highly selective “molecular tethers” for the functionalization of both natural/synthetic organic compounds and biomolecules. The envisioned tethers are bifunctional small organic molecules having three fundamental properties: 1) A “biting end” with unique reactivity to be selectively installed in situ onto naturally occurring thiols, alcohols and amines. We will use tethers based on acetals and hypervalent iodine reagents. 2) A “functional end”, whose reactivity can be revealed “at will” to functionalize bonds that cannot be accessed with the current state of the art of synthetic chemistry, especially inert C-H and C=C bonds. 3) Being traceless, meaning that they can be removed easily once the desired functionalization has been achieved. The main impact of this project will be in fundamental synthetic organic chemistry, as it will contribute to overcoming major selectivity hurdles in the functionalization of complex molecules. It will therefore result in faster progress in all the fields depending on synthetic molecules, such as medicine, agriculture or materials. A more efficient functionalization of biomolecules will allow us to soften the boundaries between synthetic chemistry and biology, leading to major progress in our understanding of living systems and our ability to modify them.

Sector Services

Contact Details

Company Name ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Address BATIMENT CE 3316 STATION 1 1015 LAUSANNE Switzerland
Web Site https://cordis.europa.eu/project/rcn/213451_en.html

9.

THE UNIVERSITY OF SHEFFIELD

Characterisation and quantification of O6-alkylguanine DNA adducts derived from nitrosated amino acids: Risk factors in colorectal cancer.

  • 195,455
  • United Kingdom
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Characterisation and quantification of O6-alkylguanine DNA adducts derived from nitrosated amino acids: Risk factors in colorectal cancer.
Company Name THE UNIVERSITY OF SHEFFIELD
Funded By European Union
Country United Kingdom , Western Europe
Project Value 195,455
Project Detail

The exposure of DNA to alkylating agents can produce base adducts such as O6-alkylguanines, that if not repaired, can lead to a variety of effects including toxicity, mutagenicity and cancer. Although exposure may be significant for certain individuals such as workers in the chemical industry and smokers, all individuals are exposed to alkylating agents from dietary components or that derive from reactive intermediates formed endogenously. For example, nitrosation of dietary amines, amino acids and their derivatives can produce reactive alkylating agents that can result in the formation of a variety of DNA base adducts. One such adduct, O6-carboxymethylguanine (O6-CMG) has been directly correlated to dietary levels of red meat, a known risk factor for developing colorectal cancer, the second most common cancer in Europe. This proposal will use novel synthetic oligodeoxyribonucleotide (ODN) and nucleoside standards to develop highly sensitive mass spectrometry-based analytical methods to identify and quantify levels of specific O6-alkylguanine adducts in DNA. This methodology will enable links to be made between exposure and cancer risk, lead to the identification of novel predictive biomarkers and benefit the assessment of human health at both the individual and population level, paving the way for more informative monitoring studies.

Sector Healthcare And Medicine

Contact Details

Company Name THE UNIVERSITY OF SHEFFIELD
Address FIRTH COURT WESTERN BANK S10 2TN SHEFFIELD United Kingdom
Web Site https://cordis.europa.eu/project/rcn/215313_en.html

10.

FORSCHUNGSVERBUND BERLIN EV

Ultrafast Structural Dynamics of Elementary Water-Mediated Proton Transport Processes

  • 2 Million
  • Germany
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Ultrafast Structural Dynamics of Elementary Water-Mediated Proton Transport Processes
Company Name FORSCHUNGSVERBUND BERLIN EV
Funded By European Union
Country Germany , Western Europe
Project Value 2 Million
Project Detail

How acids and bases react in water is a question raised since the pioneering days of modern chemistry. Recent decades have witnessed an increased effort in elucidating the microscopic mechanisms of proton exchange between acids and bases and the important mediating role of water in this. With ultrafast spectroscopy it has been shown that the elementary steps in aqueous proton transfer occur on femtosecond to picosecond time scales. Aqueous acid-base neutralization predominantly proceeds in a sequential way via water bridging acid and base molecules. These ultrafast experiments probing molecular transitions in the ultraviolet, visible and mid-infrared spectral ranges, though, only provide limited insight into the electronic structure of acids, bases and the water molecules accommodating the transfer of protons in the condensed phase. Soft-x-ray absorption spectroscopy (XAS), probing transitions from inner-shell levels to unoccupied molecular orbitals, is a tool to monitor electronic structure with chemical element specificity. The aim is now to develop steady-state and time-resolved soft-x-ray spectroscopy of acids and bases in water-poor and water-rich solutions. Here novel liquid flatjet technology is utilized with soft-x-ray sources at synchrotrons as well as table-top laser-based high-order harmonic systems, to elucidate the electronic structural evolution of proton transfer pathways. Questions to be solved are electronic structural changes upon hydrogen bond formation, the nature of hydrated proton species, and the impact of conversion from acid to conjugate base (or base to conjugate acid) in aromatic alcohols, carboxylic and amine compounds, and ultimately the oxygen oxidation state in hydrated protons. Resolving the electronic structural dynamics of elementary steps of aqueous proton transport will furthermore elucidate the role of mediating water in bulk solution, and in specific conditions such as hydrogen fuel cells or trans-membrane proteins. Expand / Contract

Sector Services

Contact Details

Company Name FORSCHUNGSVERBUND BERLIN EV
Web Site https://cordis.europa.eu/project/rcn/216232_en.html

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