The Purpose Of This Broad Agency Announcement Baa Is To Solicit Proposals For A Research Program That Includes The Comparison Of Multiple Adjuvants Using Various Vaccine Antigen Platforms The Comparative Studies Will Establish Immunological Profiles Immune Fingerprints Of Adjuvants That Work Through Different Mechanisms To Evaluate Strength Quality Breadth And Durability Of Responses Using 1 Omics Technology Platforms Such As Genomics Epigenomics Transcriptomics Rnai Screens Proteomics Metabolomics Lipidomics And Glycomics 2 T Cell Functional Assays E G Cytotoxicity Cytokine Production Epitope Specificity And 3 B Cell And Antibody Profiles To Include Assessment Of Isotype Avidity Epitope Fine Specificity And Systems Serology
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