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1.

IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE

Mechanisms and regulators coordinating replication integrity and DNA damage tolerance.

  • 2 Million
  • Italy
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Mechanisms and regulators coordinating replication integrity and DNA damage tolerance.
Company Name IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE
Funded By 38
Country Italy , Western Europe
Project Value 2 Million
Project Detail

Accurate chromosomal DNA replication is of fundamental importance for cellular function, genome integrity and development. In response to replication perturbations, DNA damage response (DDR) and DNA damage tolerance (DDT) pathways become activated and are crucial for detection and tolerance of lesions, as well as for facilitating replication completion and supporting chromosome structural integrity. While important functions and key players of these regulatory processes have been outlined, much less is known about the choreography and mechanistic interplay between DDR and DDT during replication. Moreover, the principles by which they uniquely or commonly affect replication-associated chromosome integrity remain poorly understood. Here, we will use novel tools and a palette of ingenious genetic, molecular and proteomic based experimental strategies, to investigate the replication stress response triggered by diverse endogenous and exogenous cues, and to identify the underlying mechanisms. We will define the principles of local and temporal regulation of DDT in response to genotoxic stress, with a focus on the mechanisms of SUMO-regulated DNA metabolism processes. Additionally, we will investigate the topological DNA transitions triggered at intrinsically difficult to replicate genomic regions, stalled and terminal forks, with the aim of identifying key mechanisms and regulators of replication integrity at specific complex genomic regions or following specific types of replication stress. Finally, we will explore the relationship between DDT, replication fork architecture and sister chromatid cohesion in the context of DDR- and SUMO-orchestrated DNA transactions. We expect that these studies will reveal new aspects of how replication-associated DNA metabolism processes are inter-related and regulated, uniformly or at specific loci in the genome, and will break new ground in areas of replication mechanisms and chromosome integrity in general.

Sector Administration & Marketing

Contact Details

Company Name IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE
Address Via Adamello 16 20139 Milano
Web Site https://cordis.europa.eu/project/rcn/202596/factsheet/en

2.

COVENTRY UNIVERSITY

E2-CREATE: Encoding Embodied CreativityVisual arts, performing arts, film, design

  • 21,294
  • United Kingdom
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E2-CREATE: Encoding Embodied CreativityVisual arts, performing arts, film, design
Company Name COVENTRY UNIVERSITY
Funded By 38
Country United Kingdom , Western Europe
Project Value 21,294
Project Detail

Choreography is an art form well-known for combining rigorous physical and mental training with the highest degrees of creativity. However, as dance is the most ephemeral of art forms, this extraordinary embodied creativity has been in danger of disappearing without leaving a significant trace. That was until several leading dance artists began over a decade ago to experiment with digital technology as a means to document their unique approaches to choreography. The result today is an impressive accumulation of interdisciplinary research showing how embodied creativity in dance can be systematically studied and documented, how computer-aided design can effectively communicate the outcomes and how digitised recordings can be processed computationally to reveal new information about choreographic principles, processes and methods. Drawing on these developments in dance digitisation and recent progress in computational arts, the Fellowship will focus on fusing artistic skills in dance with artistic skills in computing. The goal is to achieve a new level of sophisticated creative transfer at the intersection of the two fields by taking advantage of significant advances in the fields of computer vision and machine learning combined with the high-level of expertise the Fellow brings from the field of generative computer art. Generative computer art techniques have until now not been integrated fully into the dance digitisation process, but they have extraordinary potential in combination with machine learning to expand the capability of computational systems to learn from and model existing artistic approaches. The Fellow’s extensive experience of working at the intersection between dance technology and computer art and science means he is extremely well placed to facilitate and achieve this encoding of embodied creativity with lasting impact for mixed machine-human collaboration and interdisciplinary art and science research.

Sector Administration & Marketing

Contact Details

Company Name COVENTRY UNIVERSITY
Address Priory Street Cv1 5fb Coventry
Web Site https://cordis.europa.eu/project/rcn/222196/factsheet/en

3.

KOBENHAVNS UNIVERSITET

Sounds Delicious: A historical anthropology of listening and sound in Danish and French cooking

  • 200,195
  • Denmark
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Sounds Delicious: A historical anthropology of listening and sound in Danish and French cooking
Company Name KOBENHAVNS UNIVERSITET
Funded By European Union
Country Denmark , Western Europe
Project Value 200,195
Project Detail

The Sounds Delicious project investigates how sound and listening function in different culinary traditions in Denmark and France. The project aims to construct a new interdisciplinary dialogue between Sound Studies and Food Studies that will enrich how we study everyday cooking processes and the gustatory. This study questions how we construct cultural histories of cooking. I suggest that dominant research paradigms based on alphanumeric and visual epistemic practices (words, images, measurements) are insufficient for fully understanding the particular components and choreography of a cook’s practice—and what cooking relates about personal histories and larger social and cultural tendencies. In adopting an aural perspective of the kitchen, I engage alternative methods of perceiving evidence, and I revisit approaches of documentation, analysis and communication of the everyday. In this project sound and sonic practices are both research object and research method—both matter and medium. Sound is used to trace, analyse, even reenact different performances of cooking. I will establish a new corpus of examples documenting sound and aural perception in Danish and French kitchens between the 19th and 21st centuries. In working with a varied set of historical and anthropological tools, I will not only identify sounds in cooking, but introduce performances of cooking in relation to other histories of sonic and sensory knowing.

Sector Services Entertainment & Media

Contact Details

Company Name KOBENHAVNS UNIVERSITET
Address NORREGADE 10 1165 KOBENHAVN Denmark
Web Site https://cordis.europa.eu/project/rcn/209080_en.html

4.

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

Light-Induced Spin Switch using Dynamic Organic Species

  • 175,420
  • Switzerland
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Light-Induced Spin Switch using Dynamic Organic Species
Company Name ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Funded By European Union
Country Switzerland , Western Europe
Project Value 175,420
Project Detail

The LIDOS project uses in-silico approaches to design nanometer sized photomagnetic (PM) switches. Switches of this kind find use in myriad technological devices, primarily because of their ability to alter their magnetic response upon light irradiation. This project follows an underexplored, yet promising, strategy to obtain new PM switches with enhanced properties. Specifically, dyads (i.e. two-component molecules) will be designed that combine a photoswitch and a magnetic moiety hosting unpaired electrons. Despite attempts to design PM switches employing both transition metals and purely-organic radicals as magnetic units, significant advances in magnetic response remain elusive. This project aims to rationally develop efficient PM switches featuring pronounced changes in magnetic response at room temperature, using purely-organic components. Azobenzene and Diarylethene derivatives will serve as photoswitches, whose primary mission is undergoing a reversible structural change that modulates the magnetic interaction between the radical moieties of adjacent dyads. Thus, the design principles are based on supramolecular choreography. DTA- and Verdazyl- molecules will be targeted as radicals, and will be affixed to photoswitches via linker groups. In the first step, computational screening will be used to explore the best component combinations leading to a set of potential PM switches. In the second step, candidates will be further tuned to optimize their optical properties. The overarching goal is the identification of a reversible PM switch triggered by visible light. LIDOS lies at the intersection of photochemistry, molecular magnetism, computational chemistry, and physical organic chemistry. It combines well-established DFT-based approaches, computational methods to describe and understand non-covalent interactions recently developed at the host institution (EPFL), and state-of-the-art molecular dynamics techniques to study the photochemical process.

Sector Science And Technology

Contact Details

Company Name ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Address BATIMENT CE 3316 STATION 1 1015 LAUSANNE Switzerland
Web Site https://cordis.europa.eu/project/rcn/213980_en.html

5.

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

Light-Induced Spin Switch using Dynamic Organic Species

  • 175,420
  • Switzerland
view notice less notice
Light-Induced Spin Switch using Dynamic Organic Species
Company Name ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Funded By European union
Country Switzerland , Western Europe
Project Value 175,420
Project Detail

The LIDOS project uses in-silico approaches to design nanometer sized photomagnetic (PM) switches. Switches of this kind find use in myriad technological devices, primarily because of their ability to alter their magnetic response upon light irradiation. This project follows an underexplored, yet promising, strategy to obtain new PM switches with enhanced properties. Specifically, dyads (i.e. two-component molecules) will be designed that combine a photoswitch and a magnetic moiety hosting unpaired electrons. Despite attempts to design PM switches employing both transition metals and purely-organic radicals as magnetic units, significant advances in magnetic response remain elusive. This project aims to rationally develop efficient PM switches featuring pronounced changes in magnetic response at room temperature, using purely-organic components. Azobenzene and Diarylethene derivatives will serve as photoswitches, whose primary mission is undergoing a reversible structural change that modulates the magnetic interaction between the radical moieties of adjacent dyads. Thus, the design principles are based on supramolecular choreography. DTA- and Verdazyl- molecules will be targeted as radicals, and will be affixed to photoswitches via linker groups. In the first step, computational screening will be used to explore the best component combinations leading to a set of potential PM switches. In the second step, candidates will be further tuned to optimize their optical properties. The overarching goal is the identification of a reversible PM switch triggered by visible light. LIDOS lies at the intersection of photochemistry, molecular magnetism, computational chemistry, and physical organic chemistry. It combines well-established DFT-based approaches, computational methods to describe and understand non-covalent interactions recently developed at the host institution (EPFL), and state-of-the-art molecular dynamics techniques to study the photochemical process.

Sector Electrical

Contact Details

Company Name ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Web Site https://cordis.europa.eu/project/rcn/213980_en.html

6.

KOBENHAVNS UNIVERSITET

Sounds Delicious: A historical anthropology of listening and sound in Danish and French cooking

  • 200,195
  • Denmark
view notice less notice
Sounds Delicious: A historical anthropology of listening and sound in Danish and French cooking
Company Name KOBENHAVNS UNIVERSITET
Funded By European union
Country Denmark , Western Europe
Project Value 200,195
Project Detail

The Sounds Delicious project investigates how sound and listening function in different culinary traditions in Denmark and France. The project aims to construct a new interdisciplinary dialogue between Sound Studies and Food Studies that will enrich how we study everyday cooking processes and the gustatory. This study questions how we construct cultural histories of cooking. I suggest that dominant research paradigms based on alphanumeric and visual epistemic practices (words, images, measurements) are insufficient for fully understanding the particular components and choreography of a cook’s practice—and what cooking relates about personal histories and larger social and cultural tendencies. In adopting an aural perspective of the kitchen, I engage alternative methods of perceiving evidence, and I revisit approaches of documentation, analysis and communication of the everyday. In this project sound and sonic practices are both research object and research method—both matter and medium. Sound is used to trace, analyse, even reenact different performances of cooking. I will establish a new corpus of examples documenting sound and aural perception in Danish and French kitchens between the 19th and 21st centuries. In working with a varied set of historical and anthropological tools, I will not only identify sounds in cooking, but introduce performances of cooking in relation to other histories of sonic and sensory knowing.

Sector Services

Contact Details

Company Name KOBENHAVNS UNIVERSITET
Address NORREGADE 10 1165 KOBENHAVN Denmark
Web Site http://cordis.europa.eu/project/rcn/209080_en.html

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